N#-TOSYL-PHE CHLOROMETHYL KE 1PC X 250MG

Biochem/physiol Actions

Cell permeable: no

Reversible: no

EC50 = 20 µM in blocking the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides.

Product does not compete with ATP.

Primary Targetchymotrypsin activity in preparations

General description

This product has been discontinued.Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides (EC₅₀ = 20 M).

Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharide (EC₅₀ = 20 µM). Suggested working concentration is 10-100 µM.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Fearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.Weaver, V.M., et al. 1993. Biochem. Cell Biol.71, 488.Murakami, T., et al. 1991. Biochim. Biophys. Acta1079, 279.Nierodzik, M.L., et al. 1991. J. Clin. Invest.87, 229.Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.

Packaging

250 mg in Plastic ampoule

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

Warning

Toxicity: Irritant (B)